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Pancreas transplantation has been available for many years as an alternate therapy for Type 1 diabetes.

In June 2000, successful islet-cell transplants were announced.


Surgery to place a piece of human pancreas (either from a living related donor, or from a recently deceased organ donor) into a person with type 1 diabetes has been performed many times over the years. If the pancreas transplant is not rejected, it's quite possible for the recipient to have normal blood sugar levels, and normal glycohemoglobin levels, without any insulin injections.

But, the surgery itself is extremely complex, and the therapy that's needed to prevent the body from attacking and destroying the transplant is even more complicated. It's been commented by patients who have had transplants, that taking the anti-rejection medications is worse than having diabetes! Generally, pancreas transplants are therefore advised only for people with diabetes with some degree of problems from diabetic complications.

And transplanting a piece of pancreas is not a cure for diabetes, since putting a piece of someone else's pancreas into a person with diabetes doesn't do anything about the autoimmune process that caused the diabetes in the first place. There's still a lot of worry that if the autoimmune process is reactivated, the beta-cells of the transplant may be damaged or destroyed.

Many times in the past, a hospital has tried one or two pancreas transplants, but I would strongly advise anyone interested in learning more about this procedure to contact one of the few medical centers that have a long track record, with publications that discuss their success (and failure) rate.

Islet cell transplantation (removing the islets which contain the beta cells from a donor pancreas, and later putting these islets into a person with diabetes) is presently actively undergoing evaluation. Although transplanting islet cells may one day help people with diabetes, it must be emphasized that this procedure is still in the research stage. (See below for more links to islet cell transplantation research information.)


Also see

 other webpages about transplantation
 Pancreas Transplantation for Patients With Type 1 Diabetes, a Position Statement from the American Diabetes Association.
 Alberta Foundation for Diabetes Research "Welcome to the Alberta Foundation for Diabetes Research. Our organization is dedicated to raising funds to support research on promising treatments for Diabetes."
 Diabetes Research Institute "A recognized world leader in cure-focused research and a pioneer in islet cell transplantation..."
 Islet Cell Transplant Research Explained By Amir Hanna MB, BCH, FRCPC. At the Canadian Diabetes Association website.
 The New England Journal (2000 Jul 27;343(4):289-90) published the scientific report of the first cases. See Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-free Immunosuppressive Regimen.
 White House announcement about transplant centers receiving funding to study islet-cell transplants (July, 2000).
 Remarks by Ken Bernstein Ken is one of the growing numbers of individuals whose hope has been turned into reality through islet cell transplantation.





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Webpage updated at the DiabetesMonitor 08Feb2003
 
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