Sitagliptin (Januvia)

Sitagliptin is a prescription medication used in conjunction with exercise and diet to lower blood sugar levels in individuals with type 2 diabetes. Approved by the FDA in 2006, sitagliptin increases the production of insulin in the pancreas and reduces sugar production in the liver. It is often used in combination with other anti-diabetes medications.

Sitagliptin overview

Brand names: Sitagliptin is marketed in the United States under the name Januvia.

Brand names of medications often combined with Januvia include the following:

  • Janume, which contains metformin and sitagliptin
  • Juvisync, which contains simvastatin and sitagliptin

Drug class: Sitagliptin belongs to a class of drugs known as dipeptidyl peptidase IV (DPP-IV) inhibitors. DPP-IV inhibitors are designed to increase incretin levels, specifically GLP-1 and GIP, which then stimulates insulin production in the pancreas and signals the liver to stop producing glucose.

This class of drugs also includes the following medications:

Dosage: The recommended dose for an adult is 100 mg taken by mouth once daily. Children under age 18 or individuals with type 1 diabetes should not use this drug.

Side effects: Common side effects include runny or stuffy nose, headache, sore throat and upper respiratory infections, as well as nausea and diarrhea.

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