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Medical Conditions and Driving: Hypoglycemia Unawareness
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This report provides a comprehensive review of past and current research on the effects of medical conditions on driving performance. It is divided into 15 sections (Introduction, Vision, Hearing, Cardiovascular Diseases, Cerebrovascular Diseases, Peripheral Vascular Diseases, Diseases of the Nervous System, Respiratory Diseases, Metabolic Diseases, Renal Diseases, Musculoskeletal Disabilities, Psychiatric Diseases, Drugs, The Aging Driver, and The Effects of Anesthesia and Surgery). Each section provides a brief overview of the condition/illness; prevalence information; review of the medical, gerontological, and epidemiological literature relevant to medical conditions and driving; followed by current fitness to drive guidelines from Australia and Canada for the condition/illness. An appendix contains preliminary guidelines developed to assist physicians in determining when patients have medical conditions that can affect fitness-to-drive. This report is a scholarly but practical compendium that can serve as a valuable resource for physicians, rehabilitation practitioners, other allied health care professionals and educators, Department of Motor Vehicle personnel, road and traffic safety personnel, transportation planners, highway safety researchers, and public policymakers. Its value is particularly relevant as the driving population increases in size and age.

We reproduce the fourth part of the diabetes sections below.


Section 9: Metabolic Diseases

Hypoglycemia Unawareness

Hypoglycemic unawareness is commonly defined as an inability to recognize the autonomic symptoms (sweating, tremor, hunger, anxiety, and palpitations) of decreased plasma glucose concentrations or a failure of the warning signs to occur before development of neuroglycopenia (Gerich et al., 1991). In some European countries, unawareness of hypoglycemia is considered the most important reason for denying driving privileges to individuals with diabetes mellitus (Veneman, 1996). A review of the literature suggests that hypoglycemic unawareness is a frequent phenomenon among insulin treated diabetics. Table 27 provides a summary of those studies that have investigated the frequency of hypoglycemia unawareness in individuals with diabetes. Despite the varying methodologies (e.g., populations, categorization of hypoglycemic unawareness, retrospective versus prospective surveys, etc.), the best current estimate is that hypoglycemia unawareness occurs in about 25 percent of individuals with IDDM, with estimates ranging from eight percent to 70 percent. Bergada, Suissa, Dufresne, and Schiffrin (1989) report the highest rate (70 percent). However, their total study population consisted of 350 diabetic children and some of the episodes not preceded by warning symptoms occurred during the night. The higher rates (50 and 51 percent, respectively) reported by Arias, Kernerm Zier, Navacues, and Pfeiffer (1985) and the DCCT Research Group (1991) may be the result of therapeutic regime. In both investigations, the samples consisted of IDDM individuals undergoing intensive insulin therapy.

Table 27 Summary of Studies Investigating the Frequency of Hypoglycemia Unawareness

(Reproduced from Spinger-Verlag Diabetologica, Hypoglycemic reactions in 172 Type 1 [Insulin Dependent] diabetic patients, Gerich et al., 24, 95-99, 1991 with permission from Springer-Verlag)

Study

Subjects (n)

Unawareness (n)

Percent

Arias et al. (1985)

19

10

50

Bergada et al. (1989)

24

17

70

Berlin et al. (1987)

37

12

33

Collier et al. (1987)

49

12

25

Fui et al. (1986)

11

4

35

Goldgewicht et al. (1983)

180

36

20

Grimaldi et al. (1990)

151

26

17

Hepburn et al. (1990)

302

69

23

Mokan et al. (1991)

34

9

26

Moses et al. (1985)

52

6

12

Orchard et al. (1991)

628

126

20

Potter et al. (1982)

120

10

8

Pramming et al. (1991)

411

111

27

Ryder et al. (1990)

23

5

22

The DCCT Research Group (1991)

216

110

51

Overall Average

2257

563

25


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From the US DOT: Medical Conditions and Driving: A Review of the Literature (1960 - 2000)
undated webpages
http://www.nhtsa.dot.gov/people/injury/research/Medical_Condition_Driving/pages/Sec9-HypogUA.htm

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