This webpage is part of a series about
detection and prevention of periodontal disease in diabetes
In addition to elevated glucose levels, other changes in diabetes may predispose to periodontal disease. These include impaired leukocyte chemotaxis, phagocytosis and bactericidal activity. Impaired neutrophil function may reduce resistance to periodontal infection during periods of poor diabetic control and local relative insulin insufficiency. Other factors contributing to periodontal disease in persons with
diabetes may be altered collagen metabolism and vascular changes, including stasis in
the microcirculation.
Periodontal disease can best be described as a three-stage process starting with
gingivitis, progressing to periodontitis, and finally to advanced periodontal disease. These stages are associated with bacterial accumulations, or plaque, at and below the
gum line. As with other types of infections, these dental infections may worsen the diabetic state, resulting in hyperglycemia, fatty acid mobilization, and acidosis. Exacerbation of dental infection may undermine good diabetic control, and initial control may be difficult or impossible in a person newly diagnosed with diabetes who has active dental infection. Severe periodontal disease may also hamper systemic management by making chewing painful or difficult, leading the person to select foods that are easier to chew but which may not be nutritionally appropriate.

From the National Institute of Dental and Craniofacial Research
Detection and Prevention of Periodontal Disease in Diabetes
June 1994
http://www.nohic.nidcr.nih.gov/pubs/perdiab/risk/index.html
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